Henry is a precocious young boy, conceived in a petri-dish, raised by his single mother, Patricia, and is smarter than all of his peers. However, the one question he can't answer is, who is his father? Henry's attempts at locating his father lead him to Dr. Slavkin O'Hara, a university professor who has decided to raise his daughter, Audrey, as a psychology experiment in a world free of gender bias. Patricia starts fearing that she's losing her son, Audrey wishes she didn't have a father, Dr. O'Hara has no idea how to keep his daughter happy, and Henry may just have found the family he was looking for.

At 42, David lives the life of an irresponsible adolescent. He coasts through life with minimal effort and maintains a complicated relationship with Valerie, a young policewoman. Just as she tells him she's pregnant, David's past resurfaces. Twenty years earlier, he began providing sperm to a fertility clinic in exchange for money. He discovers he's the father of 533 children, 142 of whom have filed a class action lawsuit to determine the identity of their biological father, known only by the pseudonym Starbuck.